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Avian infectious bronchitis
Avian infectious bronchitis (IB) is an acute and highly contagious respiratory disease of chickens. The disease is caused by avian infectious bronchitis virus (IBV), a coronavirus, and characterized by respiratory signs including gasping, coughing, sneezing, tracheal rales, and nasal discharge. In young chickens, severe respiratory distress may occur. In layers, respiratory distress, nephritis, decrease in egg production, and loss of internal (watery egg white) and external (fragile, soft, irregular or rough shells, shell-less) egg quality are reported.〔Cavanagh, D., and S. A. Naqi. Infectious bronchitis. In: Diseases of
poultry, 11th ed. Y. M. Saif, ed. Iowa State University Press, Ames, IA. pp.
101–120. 2003.〕
==Etiology==
IBV was the first coronavirus described〔Almeida, J. D., D. M. Berry, C. H. Cunningham, D. Hamre, M. S. Hofstad,. L. Mallucci, K. McIntosh, and D. A. J. Tyrrell. 1968. Coronaviruses. Nature 220:650.〕 and varies greatly genetically and phenotypically, with hundreads of serotypes and strains described. Coronaviruses contain the largest known viral RNA genome in number of nucleotides, of approximately 30,000 bases. The RNA forms a single strand and single segment. IBV diversity is based on transcriptional error, which may become very relevant if occurring in genomic sequences coding for proteins, involved in adsorption to target cell or inducing immune responses. Transcriptional error variants may emerge with evolutional advantage in susceptible chickens. Large genomic changes will occur with entire gene interchanges, by reassortment, as for its replication, seven subgenomic mRNAs are produced and will enable reassortment in coinfections.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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